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The frequency rates in India begin to rise in the early thirties and peak at the age of 50–64 years 3. In general, 1 in 28 women are prone to have BC during her life span. BC is the widespread cancer in India (in women) which accounts for 14% of all the cancers in women 1, 2. Network pharmacology approach not only helps us to confirm the study of the chosen target but also gave an idea of compound-target network as well as pathways associated to the CP for treating the complex metabolic condition as breast cancer and they importance for experimental verification.īreast cancer (BC) is the malignant growth that begins in the breast cells. In addition to this animal experimentation showed that CP significantly improved immunohistological status in MNU induced carcinoma rats. The results of the western blotting showed that CP regulates ER and EGFR expression in MCF-7 cell. Furthermore, on the basis of the above results the important proteins were fetched for the docking study which helps in predicting the possible interaction between components and targets. Compound-target network involves 4 active compound and 150 target genes which elucidate the mechanisms of drug action in breast cancer treatment.
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The results found by PPI states that our network has significant interactions which include the ESR-1, ESR-2, ESRRA, MET, VEGF, FGF, PI3K, PDK-1, MAPK, PLK-1, NEK-2, and GRK. The results for the analysis were as among 29 components, only four components were found active for further study which proved the use of CP as a multi-target herb for betterment of clinical uses. In the present study, bioactive components and potential targets in the treatment of breast cancer validated through in silico, in vitro and in vivo approach. Caesalpinia pulcherima (CP) is a traditional herb used for the treatment of asthma, bronchitis, cancer, anti-bacterial, anti-fungal and as abortifacient.